How is gout caused?

The specific etiology and pathogenesis of gout is not clear, but it is closely related to hyperuricemia.

Uric acid excretion disorder or excessive uric acid production may lead to purine metabolism disorder, resulting in hyperuricemia. If it is not controlled, it may develop into gout in the long run. Eating a large amount of purine-rich foods, such as animal internal organs and some seafood, may lead to excessive uric acid production. Long-term use of thiazide diuretics, cyclosporine, etc. may affect kidney function and lead to uric acid excretion disorder. In addition, obesity, diabetes and other diseases are also related to hyperuricemia.