What is the difference between hepatitis B small Sanyang and hepatitis B big Sanyang

Hepatitis B small three positive refers to hepatitis B surface antigen, hepatitis B e antibody, hepatitis B core antibody three positive, and hepatitis B big three positive refers to hepatitis B surface antigen, hepatitis B e antigen, hepatitis B core antibody three positive, generally speaking, big three positive virus replication is more active, infectious strong, small three positive tips in chronic disease, infectious weak.