What are the causes of bipolar disorder?

Bipolar disorder is caused by biochemical factors, environmental and psychosocial factors, and brain structural abnormalities.

1. Biochemical factors such

as neurotransmitter imbalances, endocrine system disorders, and brain neural network abnormalities may lead to bipolar disorder.

2. Environmental and psychosocial factors

Stress events in life, such as interpersonal problems, unemployment, death of loved ones, or divorce, may trigger the onset of bipolar disorder.

3. Brain structural abnormalities such

as amygdala, hippocampus, and prefrontal cortex volume and function abnormalities. These brain structural abnormalities may lead to bipolar disorder, and are generally related to emotional regulation and cognitive function.