What causes high blood sugar in pregnant women?

Pregnant women show high blood sugar is mainly due to the increase of antagonistic insulin-like substances in pregnant women, such as tumor necrosis factor, leptin, placental lactogen, estrogen, progesterone, cortisol and placental insulinase, so that pregnant women's sensitivity to insulin decreases with the increase of gestational age. In order to maintain normal glucose metabolism, insulin requirements must be increased accordingly. For pregnant women with limited insulin secretion, this physiological change cannot be compensated during pregnancy, which will cause blood glucose to rise, indicating gestational diabetes or worsening of existing diabetes. The impact of gestational diabetes on mothers and infants is relatively large, especially due to the condition of diabetes and poor blood sugar control, including macrosomia, fetal growth restriction, easy to show miscarriage and premature delivery, fetal distress and even intrauterine death.