Principles of Chemotherapy

The principle of chemotherapy is to use chemical drugs to interfere with cell proliferation, induce apoptosis, inhibit angiogenesis, destroy the metabolism of cancer cells, and finally kill cancer cells. They inhibit the growth of cancer cells by interfering with DNA synthesis, repair or blocking key processes needed for cell division.2. Inducing Apoptosis Many chemotherapy drugs trigger the apoptosis mechanism of cancer cells.Apoptosis is a programmed cell death process that causes cancer cells to self-destruct. Drugs can induce apoptosis by affecting intracellular signaling pathways and destroying cell structure and function. 3. Inhibition of angiogenesis The growth and metastasis of cancer cells require new blood vessels to provide nutrients and oxygen. Chemotherapy drugs can inhibit vascular endothelial growth factor and other factors that promote angiogenesis, thereby reducing the formation of new blood vessels in tumors, limiting the nutrient supply of cancer cells, inhibiting their growth and proliferation. Chemotherapy drugs can interfere with the metabolic pathways specific to cancer cells, affecting their energy production and substance synthesis, resulting in cancer cell dysfunction and death. It should be noted that although chemotherapy has significant inhibition and killing effects on cancer cells, it will also produce certain toxicity and adverse reactions to normal cells. When chemotherapy is performed, doctors will weigh the treatment effect and side effects according to the specific conditions of patients and formulate individualized chemotherapy regimens to maximize the efficacy and reduce the impact of adverse reactions on the quality of life of patients.

At the same time, combined with other treatment methods, such as surgery, radiotherapy, immunotherapy, etc., often can obtain better treatment results.