How to check tuberculosis resistance

TB drug resistance examination mainly includes sputum smear and culture, drug sensitivity test, molecular biology test, imaging examination, clinical symptoms and signs, etc. Doctors will choose appropriate methods according to the patient's situation to make comprehensive judgment. TB drug resistance examination mainly includes the following: 1. Sputum smear and culture: This is the basic method of tuberculosis diagnosis, but also an important means of detecting drug resistance. Through sputum smear to find acid-fast bacilli, cultured tuberculosis bacteria can be drug sensitivity test, to understand the sensitivity of tuberculosis bacteria to drugs. 2. Drug sensitivity test: drug sensitivity test can detect tuberculosis bacteria to a variety of anti-tuberculosis drugs, including first-line drugs and second-line drugs. The commonly used drug sensitivity test methods include absolute concentration method, proportion method and microbroth dilution method. 3. Molecular biology detection: Molecular biology detection methods such as PCR amplification and sequencing can detect the drug resistance gene mutation of tuberculosis bacteria, such as rpoB, katG, inhA and other gene mutations, so as to judge the drug resistance of tuberculosis bacteria. 4. Imaging examination: Chest X-ray or CT examination can help doctors understand the lung lesions, assess the severity of tuberculosis and treatment effect.5. Clinical symptoms and signs: The doctor will ask the patient's symptoms in detail, such as cough, expectoration, hemoptysis, low fever, night sweats, etc., as well as physical examination, observe lung auscultation, judge the progress of the disease and treatment effect. It should be noted that the examination of TB drug resistance needs to be carried out in a professional medical institution. The doctor selects the appropriate examination method according to the specific situation of the patient, and makes a comprehensive judgment based on the clinical symptoms and treatment response. At the same time, patients should take medicine strictly according to the doctor's advice during the treatment process, and review regularly to ensure the treatment effect and prevent the occurrence of drug resistance. TB resistance testing and treatment may vary for specific populations, such as children, the elderly, immunocompromised individuals, etc. Doctors will develop individualized treatment plans based on individual circumstances and closely monitor treatment outcomes and adverse reactions. In addition, family members and close contacts of drug-resistant TB patients should also be examined and preventive measures should be taken to prevent the spread of drug-resistant TB bacteria. In short, the examination of drug resistance to tuberculosis is an important link in the treatment of tuberculosis, which is of great significance for selecting appropriate treatment options and improving treatment results. Patients should actively cooperate with doctors for examination and follow doctors' treatment suggestions for early recovery.