Is there a high risk of gastric cancer without infection with Helicobacter pylori?

The risk of stomach cancer without H. pylori infection is generally not high, because H. pylori infection in the stomach is an important factor in inducing stomach cancer. However, even without H. pylori infection, stomach cancer may occur. Because the risk factors for stomach cancer include genetic factors, environmental factors, dietary factors and precancerous lesions. If there are symptoms such as epigastric pain, epigastric palpable mass, anorexia, anemia, etc., the patient needs to actively do gastroscopy, and pathological biopsy should be taken if suspicious lesions are found, which has the effect of excluding gastric malignant diseases.