Causes of diabetes insipidus:

Diabetes insipidus is a neuroendocrine or renal disorder. It is mainly associated with varying degrees of arginine vasopressin deficiency or renal insensitivity to arginine vasopressin. The most common causes include central diabetes insipidus and renal diabetes insipidus. Central diabetes insipidus is a variety of causes affecting arginine vasopressin synthesis, transport, storage and release. It can be divided into acquired central diabetes insipidus, hereditary central diabetes insipidus and idiopathic central diabetes insipidus. Renal diabetes insipidus is divided into congenital renal diabetes insipidus and acquired renal diabetes insipidus. Congenital renal diabetes insipidus is caused by a mutation in the vasopressin V2 receptor gene or aquaporin-2 gene. Acquired renal diabetes insipidus is mainly caused by drugs, hypercalcemia, and prolonged severe hypokalemia.