Glomerular disease appears a lot of proteinuria what reason

Glomerular diseases occur a large amount of proteinuria mainly because of glomerular filtration barrier damage caused.

There are many glomerular diseases, such as acute glomerulonephritis, IgA nephropathy, diabetic nephropathy, membranous nephropathy, etc. The glomerular filtration barrier is divided into molecular barrier and charge barrier, under normal circumstances only small protein molecules and positively charged plasma protein filtration. In the filtration barrier damage, protein filtration excess will increase, exceeding renal tubular reabsorption capacity, resulting in a large amount of proteinuria. If there are still immunoglobulin, complement C3, etc. in urine, it is suggested that the glomerular filtration membrane structure is more seriously damaged.