What are the causes of high CSF leukocytes and high protein?

Cerebrospinal fluid white blood cells high, high protein, the most common reason is infectious diseases. Hydrocephalus is a colorless and transparent liquid existing in the ventricles and subarachnoid space, secreted by the choroid plexus of the lateral ventricles, absorbed by arachnoid granules, normal adults secrete cerebrospinal fluid volume is about 500mL per day, and ventricles and subarachnoid space, can hold about 130mL cerebrospinal fluid. Brain and spinal cord contain a large number of protein substances, any cause of brain and spinal cord injury, can show elevated protein in cerebrospinal fluid, while normal only infectious diseases cause elevated white blood cells, so elevated white blood cells and protein in cerebrospinal fluid, more common cause is infection. Common causes include viral encephalitis, purulent meningitis, tuberculous meningitis, mylitis, Guillain-Barre syndrome, etc. The whole number of white blood cells in viral encephalitis is dozens times 10^6/L, generally no more than 50×10^6/L, while the total number of white blood cells in tuberculous meningitis is normally 50-500×10^6/L, and the total number of white blood cells in purulent meningitis is very high, which can reach thousands times 10^6/L. In addition to laboratory tests, the patient's physical signs must be observed to pinpoint whether it is intracranial infection or spinal cord disease.