Drugs inhibiting gastric acid secretion and their mechanism of action

There are two main types of drugs that can inhibit gastric acid: one, hydrogen ion receptor antagonists, including cimetidine, ranitidine, famotidine, etc., which block the hydrogen ion receptor of d cells and inhibit gastric acid secretion. The effect of inhibiting gastric acid secretion is 50% stronger than that of anticholinergic drugs. Proton pump blockers, omeprazole, lansoprazole, pantoprazole, rabeprazole, its role in inhibiting hydrogen ion-potassium ion-ATPase, so that hydrogen ions and potassium ions can not be exchanged, so that hydrogen ions can not be discharged, gastric acid can not be synthesized, for the strong inhibition of gastric acid secretion drugs. Applicable to active ulcer disease, refractory ulcer disease, Zhuo Ai syndrome and so on.