Syphilis has no clinical symptoms.

The symptoms vary according to the infection and incubation time. Patients with primary syphilis may develop portal ulcers, chancre, and itchy skin. Patients with secondary syphilis may develop rashes, erythema, desquamation, and eczema. Tertiary syphilis may endanger entire body organs, such as cardiovascular syphilis, nervous system syphilis, and joint pain.