What is the difference between hand, foot and mouth disease and chickenpox?

Hand, foot and mouth disease is caused by enterovirus infection, of which coxsackie virus A16 and enterovirus 71 are more common. Chickenpox is caused by varicella-herpes zoster virus infection. Chickenpox rash is concentric distribution, more common on the trunk, less common on the palms and feet; hand, foot and mouth disease rash distribution is opposite to chickenpox rash distribution.