What is acute disseminated encephalomyelitis?

Acute disseminated encephalomyelitis is an inflammatory demyelinating disease of the central nervous system, which can extensively involve the white matter of the brain and spinal cord. The patient has an acute onset and often has a history of infection or vaccination before the disease. The pathological features are multifocal and diffuse demyelination. The pathogenesis is not completely clear at this stage. It is considered to be related to virus infection and excessive activation of the body's autoimmune function after vaccination. The main clinical symptoms of the patient are various, sometimes showing sudden high fever, headache, general soreness, severe seizures, obvious disturbance of consciousness, resulting in lethargy and coma; paraplegia or quadriplegia when the spinal cord is involved; dyskinesia when the extrapyramidal system is involved, manifested as limb tremor or involuntary movement; dizziness, unstable walking, ataxia when the cerebellum is involved.