Clinical manifestations of white matter demyelination

The clinical manifestations of white matter demyelination are varied, depending on the location and type of lesion. Patients can clinically present with visual impairment, limb weakness, paresthesia, total disorder, etc. Patients can show autonomic nervous dysfunction, mental symptoms and cognitive dysfunction. White matter demyelination refers to a group of diseases that occur in the brain and are characterized by demyelination of neuronal cell bodies and axons, including hereditary and acquired two types of hereditary white matter demyelination diseases. It mainly refers to white matter, dystrophy, acquired white matter demyelination disease, mainly including multiple sclerosis, concentric sclerosis, pontine central myelinolysis, diffuse sclerosis and radiation encephalopathy.