Anticoagulant therapy for ischemic stroke with atrial fibrillation

Atrial fibrillation is one of the most common causes of ischemic stroke. Atrial fibrillation refers to the rapid and irregular impulse of atrial ectopic pacemaker, which causes atrial contractility to be obviously weakened, blood flow is slow, turbulence is formed in the atrium, and then mural thrombus is formed. When emboli fall off, 3/4 of them cause cerebral embolism. The mural thrombus belongs to venous thrombosis, which is a red thrombus formed due to blood coagulation. Warfarin is the most commonly used anticoagulant drug. Warfarin is therefore the gold standard for secondary prevention of ischemic stroke associated with atrial fibrillation. The target dose is to maintain an international normalized ratio of 2 to 3, achieving an optimal balance between efficacy and safety.