What are the clinical manifestations of cold urticaria?

Cold urticaria can be divided into two types, one is familial, autosomal dominant inheritance, rare, shortly after birth or early onset, skin lesions repeatedly manifested throughout life, the other is acquired, more common, manifested as exposure to cold air or cold water or cold things, exposure or contact parts produce wheals or plaque edema, serious patients can show hand numbness, lip numbness, chest distress, palpitations, abdominal pain, diarrhea, syncope, even shock, etc Sometimes eating cold drinks can cause oral and laryngeal edema, cold urticaria patients ice test or cold water immersion test positive. This disease can be one of the clinical manifestations of certain diseases, such as cryoglobinemia, paroxysmal cold hemoglobinuria, etc.