What is the main pathogenesis of glomerular disease?

The pathogenesis of glomerular disease is mainly related to immune-mediated inflammation. The following is a general answer based on this major pathogenesis: 1. Immune response: The occurrence of glomerular disease is closely related to abnormal immune mechanisms. Antibodies or immune complexes produced in the body deposit in the glomerulus, activating the complement system, resulting in inflammatory response. Inflammatory response can damage glomerular filtration membrane, which in turn affects kidney function.2.Inflammatory mediator release: immune complexes activate inflammatory cells, releasing a variety of inflammatory mediators. These inflammatory mediators further exacerbate glomerular inflammation and damage.3.Genetic factors: Certain genetic factors may increase an individual's susceptibility to glomerular disease. Specific gene mutations or polymorphisms may affect immune system function or glomerular structure. 4. Environmental factors: Environmental factors such as infections, drugs, and poisons may also trigger glomerular disease. These factors may cause disease through immune regulation or direct damage to glomeruli. 5. Other factors: Hemodynamic changes, metabolic disorders and other factors may also be involved in the occurrence and development of glomerular disease. It should be noted that the specific pathogenesis of glomerular disease may vary according to individual differences and disease types. For patients with glomerular disease, early diagnosis and treatment are essential to reduce inflammation, protect kidney function and prevent complications. Treatment methods include immunosuppressants, antihypertensive drugs, lipid-lowering drugs, etc. Specific treatment programs should be formulated according to the specific conditions of patients.

At the same time, patients also need to pay attention to rest, diet control and regular follow-up to maintain kidney health. If you or someone close to you has glomerular disease-related problems, it is recommended to consult a professional in time for personalized treatment advice.