Chemotherapy after colon cancer surgery

FOLFOX regimen is a chemotherapy regimen based on oxaliplatin, fluorouracil and calcium folinate. Oxaliplatin has strong antitumor activity and can effectively inhibit the proliferation of tumor cells. Fluorouracil is a commonly used antitumor drug that acts by interfering with nucleic acid synthesis in tumor cells; calcium folinate enhances the efficacy of fluorouracil. The regimen is effective, but may cause some adverse reactions, such as neurotoxicity and gastrointestinal reactions. 2. FOLFIRI regimen contains irinotecan, fluorouracil and calcium folinate. Irinotecan inhibits topoisomerase I, thereby inhibiting tumor cell division; similarly, fluorouracil and calcium leucovorin synergize to exert antitumor effects. This regimen can also achieve good results in some cases, but there are also some side effects, such as diarrhea, bone marrow suppression, etc. When selecting chemotherapy regimen, doctors will comprehensively consider the specific conditions of patients, such as pathological characteristics of tumors, physical conditions and tolerability of patients, etc. Meanwhile, during chemotherapy, patients need to be closely monitored for adverse reactions and timely adjust treatment regimen to ensure the safety and effectiveness of treatment. In addition, nutritional support and psychological counseling of patients are also aspects that cannot be ignored in the treatment process, which help to improve patients' tolerance to chemotherapy and quality of life.