Chemo before surgery.

The main reasons for chemotherapy before surgery are to reduce tumor size, eliminate potential micrometastases, evaluate tumor response to chemotherapy, and improve surgical tolerance. Especially for some patients with large tumor size and wide invasion range, chemotherapy can reduce the tumor to a more suitable range for surgical resection, and improve the success rate and radical effect of surgery. Chemotherapy can act systemically on tumor cells, including those with potential micrometastases, thus reducing the risk of recurrence and metastasis after surgery. 3. Assessing tumor response to chemotherapy By first chemotherapy, tumor response to chemotherapy drugs can be observed to assess tumor biology and prognosis. If the tumor is sensitive to chemotherapy, it indicates that the treatment plan may be effective, and it can also provide important reference basis for subsequent treatment.4. Improve the tolerance of surgery Some patients may not be able to bear the trauma and stress of surgery immediately due to physical conditions. Chemotherapy first can improve the patient's physical condition to a certain extent, improve its tolerance to surgery, and ensure the smooth operation and postoperative recovery. Chemotherapy first before surgery is a treatment strategy after comprehensive consideration of various factors, aiming to improve the treatment effect, reduce the risk and bring better treatment outcome for patients. However, the specific treatment plan should be determined after full evaluation and discussion by a multidisciplinary medical team according to the individual situation of the patient.