The difference between primary gout and secondary gout

There are significant differences between primary gout and secondary gout in etiology, pathogenesis and treatment. 1. Different etiologies of primary gout mostly stem from genetic defects or congenital purine metabolism disorders, such as polygenic genetic defects leading to renal tubular secretion of uric acid dysfunction, uric acid excretion decreased, induced hyperuricemia and gout. Secondary gout is often caused by other diseases or drugs, such as abnormal renal function, hypertensive nephropathy, drug reactions, etc., resulting in reduced or increased uric acid excretion. 2. The incidence of primary gout is relatively low, can occur in any age group, but more common in middle-aged men. The symptoms are diverse and may be severe, including joint pain, swelling, limited mobility, etc., even accompanied by fever, headache and other systemic symptoms. Secondary gout is mostly secondary to the elderly, its symptoms are often related to the original disease, and the course may be longer. 3. Treatment differences Primary gout treatment needs long-term management, including diet control, drug therapy and lifestyle changes. The treatment of secondary gout is mainly aimed at the original disease, and the treatment effect of gout depends on the control of the original disease. There are obvious differences between primary gout and secondary gout in etiology, morbidity characteristics and treatment, so diagnosis and treatment should be carried out according to specific conditions.