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Nt belongs to the early Tang screen, generally 1113 weeks of pregnancy plus 6 during the examination, mainly to check the fetal genetic abnormalities, to rule out the risk of fetal Down's. Four-dimensional color Doppler examination can rule out the fetal body various organ abnormalities, nt does not mean that four-dimensional color Doppler must pass through. Then there will be changes in various stages of fetal development. During the 1520 weeks plus six weeks of pregnancy, it is also recommended to do Tang screening and four-dimensional color Doppler ultrasound to exclude fetal malformation. If necessary, amniotic fluid puncture is needed to exclude fetal malformation. Regular prenatal examination is needed during pregnancy.