How to diagnose hepatolenticular degeneration

Hepatolenticular degeneration can be diagnosed by serum ceruloplasmin and copper oxidase activity, body trace copper, imaging examination, liver and kidney function examination, slit lamp examination, etc., as follows: 1. Ceruloplasmin and copper oxidase activity Normal ceruloplasmin value is 0.26 - 0.36g/L. If the serum ceruloplasmin of the subject is reduced, the possibility of hepatolenticular degeneration is considered to be greater. 2. Trace copper in the body. The urinary copper excretion of normal people is below 50 μ g/24 h, and the liver copper concentration is 20 - 45 μ g/g dry weight. 3. Imaging examination of hepatolenticular degeneration. Brain CT examination showed brain atrophy and ventricular enlargement, bilateral symmetrical basal ganglia low density. CT low density on MRI performance for T1 low signal, T2 high signal. 4, liver and kidney function examination if serum total protein decreased, Y-globulin increased, creatinine increased, suggesting different degrees of liver and kidney function damage. 5, slit lamp examination hepatolenticular degeneration patients do slit lamp examination, visible corneal limbus brown green ring.