How does rheumatic fever arise?

Rheumatic fever is caused by group A hemolytic streptococci infection, the specific pathogenesis has not been completely clear.

Rheumatic fever belongs to autoimmune diseases, clinical at present that streptococci antigen and human tissue cross-antigenicity, in group A hemolytic streptococci infection will produce a large number of autoantibodies and activate T cells, autoantibodies and streptococci antibody reaction will also occur with the body's own antigen reaction, thus causing arthritis, carditis, circular erythema, subcutaneous nodules and other self-injury.