How is nephroblastoma caused?

Nephroblastoma is an embryonal malignancy that occurs most frequently in children under three years of age and is the second most common abdominal malignancy in children. The exact etiology of nephroblastoma is unknown. It may be related to a loss or mutation of the wt-1 gene on chromosome 11, or it may be caused by the failure of mesenchymal embryonal cells to differentiate into retrorenal tissues and continue to proliferate. The disease also has a certain familial tendency, so some people think that the disease is also hereditary. The above health science knowledge is for reference only, and the specific situation needs to be seen in a regular hospital so that doctors can check and treat it in time. Do not diagnose and treat yourself.