Mitral valve closure is caused by heart failure.

The causes of mitral valve insufficiency include congenital malformations, coronary atherosclerotic heart disease, left ventricular enlargement, etc.

1. Congenital malformations

Congenital malformations include endocardial cushion defects often combined with mitral valve anterior leaflet cleft, due to the valve leaflets do not coapt with each other, resulting in mitral valve insufficiency.

2. Coronary atherosclerotic heart disease

Patients with coronary atherosclerotic heart disease, due to the disease involving papillary muscle and its adjacent ventricular wall myocardium, leading to papillary muscle fibrosis and dysfunction, resulting in mitral valve insufficiency.

3. Left ventricular

enlargement caused by any disease, such as hypertension, long-term myocardial ischemia, etc., may lead to mitral valve ring dilatation and papillary muscle lateral shift, thus affecting the closure of the valve leaflets, resulting in mitral valve insufficiency.