The factors associated with peptic ulcer are

Helicobacter pylori infection, gastric acid and pepsin secretion, drug factors, genetic factors, mental and psychological factors, bad living habits, gastric and duodenal abnormal movement, etc. 1. Helicobacter pylori infection This is an important pathogenic factor for peptic ulcer. Helicobacter pylori can destroy the gastric mucosal barrier, making it vulnerable to gastric acid and pepsin.2. Excessive secretion of gastric acid and pepsin Gastric acid and pepsin digestion of gastric mucosa is the direct cause of ulcer formation. When gastric acid secretion is excessive or pepsin activity is enhanced, the gastric mucosal defense mechanism may not be effective, thus causing ulcers. 3. Drug factors Long-term use of non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen, etc., can damage gastric mucosa and increase the risk of peptic ulcer. 4. Genetic factors Genetic susceptibility may play a role in the pathogenesis of peptic ulcer, and abnormalities in some genes may make individuals more susceptible to peptic ulcer. 5. Mental psychological factors such as excessive tension, anxiety and stress may affect the nervous system and endocrine system, leading to abnormal gastric acid secretion, etc., and then promote the occurrence of peptic ulcer. 6. Bad living habits Smoking can increase gastric acid secretion, reduce duodenal bicarbonate secretion, and reduce pyloric sphincter tension, thereby increasing the incidence of peptic ulcer. Bad eating habits such as alcoholism and overeating may also cause damage to the gastric mucosa. 7. Abnormal gastroduodenal motility, delayed gastric emptying or abnormal movements such as duodenogastric reflux may expose the gastric mucosa to gastric acid. Prolonged, increasing the chance of injury.