B27 negative can rule out ankylosing spondylitis?

B27 negativity generally does not rule out ankylosing spondylitis, a chronic inflammatory disease that affects the spine, sacroiliac joints, and peripheral joints. B27 is the abbreviation of human leukocyte antigen B27, which is often used in the auxiliary diagnosis of ankylosing spondylitis, but about 10% of ankylosing spondylitis patients B27 test is negative. The diagnosis of ankylosing spondylitis needs to combine clinical symptoms, signs, imaging and laboratory tests and other factors. Common symptoms include low back pain, morning stiffness, and limited spinal mobility. Imaging studies such as X-rays, CT scans, or MRI scans can reveal inflammation and structural changes in the spine. Laboratory tests such as erythrocyte sedimentation rate and C-reactive protein may also be performed. Although B27 negative can not rule out ankylosing spondylitis, but if B27 positive, accompanied by related clinical symptoms and signs, the diagnosis of ankylosing spondylitis has a certain role in prompting. It should be noted that the diagnosis of ankylosing spondylitis is more complex, and should be comprehensively evaluated and judged by professional doctors. If ankylosing spondylitis is suspected, it is recommended to see a doctor in time for further examination and treatment. At the same time, maintaining good living habits, such as proper exercise, maintaining correct sitting and standing posture, is also very important for preventing and controlling the disease.