Causes of high total bilirubin and indirect bilirubin

The main causes of high bilirubin are: 1. Tumor, stone and obstruction in liver cause bile flow obstruction. Liver plays an important role in bilirubin metabolism, including liver cells 'uptake, combination and excretion of unbound bilirubin in blood. Any one of these processes can cause bilirubin to accumulate in blood and show jaundice. 2. Damage to liver cells. The causes of high indirect bilirubin are: 1. Increased cell destruction, infection, etc. 2. Liver disease. Such as chronic active hepatitis, cirrhosis, etc.