What is the cause of massive proteinuria in nephrotic syndrome

Nephrotic syndrome is diagnosed by a large amount of urine protein, 24 h UP quantitative more than 3.5 g, plasma albumin level less than 30g/L. The main reason for the large amount of urine protein in patients is that the glomerular filtration barrier is damaged.

Under normal circumstances, glomerulus is a group of capillaries, with semi-permeable effect. When blood passes through this group of capillaries, metabolic waste and water in blood will be filtered out, while protein and red blood cells in blood will remain in the body, and it is difficult to enter urine.

When some cause damages glomerulus, causing damage to glomerular filtration barrier, blood passing through this group of capillaries may exclude metabolic waste and protein components from the body, so it will cause large amounts of urine protein in patients with nephrotic syndrome.

Common causes include chronic nephritis, diabetes, systemic lupus erythematosus, allergies and other factors, which can damage glomerular filtration barrier.