How to diagnose aristolochic acid nephropathy

Histopathological examination:

1. Acute aristolochic acid nephropathy: Pathological manifestation was acute renal tubular necrosis. Electron microscope (electron microscope) examination showed that renal tubular epithelial cells microvilli shed, mitochondria swollen and mitochondrial crista disappeared, some organelles disintegrated, basement membrane exposed. 2. Chronic aristolochic acid nephropathy: Pathological manifestation was chronic

tubulointerstitial nephropathy. Electron microscope examination showed a large number of bunchy collagen fibers in renal interstitium, thickening and stratification of renal tubular components, and ischemic shrinkage of basement membrane in part. 3

. Renal tubular dysfunction aristolochic acid nephropathy: Pathological manifestation was renal tubular degeneration. Electron microscope examination showed partial shedding of proximal tubular epithelial cells microvilli, mitochondrial swelling of renal tubular epithelial cells, and partial organelle disintegration.