Syphilis double positive and single positive difference

The difference between syphilis double positive and single positive mainly lies in the different performance of detection indicators.

Syphilis double positive refers to syphilis specific antibodies (e.g. TPPA) and non-specific antibodies (such as RPR, etc.) are positive. This means that patients are not only infected with syphilis, and may be currently in the active stage, infectious, need timely standardized treatment. This situation suggests that Treponema pallidum infection is more clear, and the disease may be progressing or persistent.

Syphilis is positive in two cases. One is syphilis specific antibody positive, while non-specific antibody negative, may suggest that syphilis has been infected in the past, but has been cured or in a stable state, generally not infectious, but still need regular review to monitor changes in the condition.

Another situation is syphilis specific antibody negative, but non-specific antibody positive, this situation is relatively complex, there may be false positive, such as recent other infections, autoimmune diseases, etc., need to further combine clinical symptoms, medical history, etc. for comprehensive judgment and identification, if necessary, repeat detection or other relevant examinations to confirm diagnosis.