What are the symptoms of gastrinoma

Typical symptoms of gastrinoma include persistent and severe epigastric pain accompanied by acid reflux. Regular use of anti-ulcer drugs is ineffective and prone to recurrence. Some patients may also exhibit hematemesis and black stools, and may also exhibit diarrhea. In severe cases, patients may exhibit hypokalemia and malabsorption of fat and vitamin B12, and may also exhibit severe dehydration. Most importantly, patients may exhibit endocrine symptoms, possibly accompanied by thyroid adenoma and hyperparathyroidism. As the disease progresses, patients may also exhibit gastrointestinal perforation and gastrointestinal bleeding.