Etiology of chronic acalculous cholecystitis

Chronic acalculous cholecystitis is a chronic inflammatory disease of the gallbladder. The etiology is not completely clear, but it is related to many factors. The following is a specific analysis of the etiology of chronic acalculous cholecystitis: 1. Abnormal gallbladder dynamics: gallbladder motor dysfunction, delayed emptying, leading to cholestasis, conducive to bacterial reproduction and stimulation of cholesterol salts, and then cause cholecystitis. 2. Cholestasis: imbalance of cholesterol salts, cholesterol, phospholipids and other components in bile, cholesterol supersaturation, easy to form cholesterol crystals and precipitation, and then stimulate gallbladder mucosa, causing inflammation. 3. Bacterial infection: Bacterial infection is one of the important causes of chronic non-calculous cholecystitis. Common pathogens include Escherichia coli, Klebsiella, etc. These bacteria can infect the gallbladder through retrograde biliary tract infection or blood circulation. 4. Biliopancreatic reflux: The reflux of biliary and pancreatic juice can activate pancreatic enzymes and destroy the barrier function of gallbladder mucosa, resulting in inflammation and damage. 5. Ischemia: insufficient blood supply of gallbladder artery, such as atherosclerosis, myocardial infarction, etc., can lead to ischemia and necrosis of gallbladder mucosa, and then cause inflammation. 6. Other factors: neuroendocrine disorders: autonomic nervous dysfunction, affecting gallbladder contraction and emptying function. Immune factors: abnormal immune function may be involved in the occurrence and development of chronic non-calculous cholecystitis. Genetic factors: Certain genetic mutations or familial conditions may increase the risk of chronic non-calculous cholecystitis. Dietary factors: A high cholesterol, high fat diet may promote the formation of gallstones and cholecystitis. It should be noted that the cause of chronic non-calculous cholecystitis may be the result of a combination of factors. For patients, it is very important to seek medical attention in time, identify the cause, and take appropriate treatment measures. At the same time, maintaining a healthy lifestyle, such as reasonable diet, moderate exercise, smoking cessation and alcohol restriction, can also help prevent and control the development of chronic non-calculous cholecystitis. Key information: 1. The etiology of chronic acalculous cholecystitis includes abnormal gallbladder dynamics, cholestasis, bacterial infection, cholangiopancreatic reflux, ischemia and other factors. 2. Clarifying the etiology is very important for the treatment and prevention of the development of chronic acalculous cholecystitis. 3. Maintaining a healthy lifestyle is helpful to prevent and control chronic acalculous cholecystitis.