What are the diagnostic criteria for mixed connective tissue disease?

The main diagnostic criteria for mixed connective tissue disease include severe myositis, lung involvement, decreased esophageal motility, joint swelling, tenderness, hardening of the fingers, positive antinuclear antibodies or ENA antibodies. Leukopenia and thrombocytopenia may also assist in the diagnosis. In addition, positive antinuclear antibodies may initially confirm mixed connective tissue disease.