Clinical significance of urinary immunoglobulin g

Urinary immunoglobulin G exceeding the reference range indicates severe impairment of glomerular function. once urinary immunoglobulin G is positive, it indicates non-selective proteinuria, which often indicates poor prognosis. In terms of renal function, glomerular filtration function is an important component, and there are many ways to test glomerular filtration function, including urinary immunoglobulin G. Immunoglobin G has a molecular weight of 150KD. Under normal circumstances, immunoglobulin G in the blood cannot pass through the glomerular filter membrane due to the molecular sieve effect of the glomerular filter membrane. When the glomerulus is severely damaged, the effect of the glomerular molecular sieve is significantly reduced, resulting in the expression of immunoglobulin G in urine. Therefore, the detection of urinary immunoglobulin G is mainly aimed at the detection of glomerular filtration.