Symptoms of bilirubin encephalopathy

Bilirubin encephalopathy refers to high unconjugated bilirubin, free bilirubin, through the blood-brain barrier, can be deposited in the basal ganglia nucleus, thalamus, hypothalamic nucleus, cerebellum medulla, including cerebral cortex, spinal cord and other parts, inhibiting the brain tissue to oxygen utilization, thus causing brain damage in these parts, resulting in a series of clinical manifestations. Clinical manifestations are divided into 4 stages, 1-3 in the early neonatal period, the fourth stage is after the neonatal period. Warning period mainly manifested as lethargy, sucking reflex weakened, muscle tension decreased. Spastic period, light is two eyes gaze, paroxysmal muscle tension increased, severe can cause both hands clench, angle arch inverted. In the recovery period, about the end of the first week, first sucking force and reaction to the outside world gradually recovered, and then the spasm gradually reduced, disappeared, about two weeks; Sequela stage performance from birth two months, or later, can be manifested as athetosis, eye movement disorders, mental retardation and other clinical manifestations.