Pathogenesis of hepatic encephalopathy

The pathogenesis of hepatic encephalopathy, mainly has the following kinds: First, ammonia poisoning theory. It is the main point of view at this stage, due to the increase in blood ammonia, resulting in metabolism and dysfunction in brain tissue. Ammonia can interfere with brain energy metabolism, change the content of neurotransmitters in the brain, affect excitatory conduction. Second, pseudo-neurotransmitter theory. Severe liver disease, pseudo-neurotransmitters, in the brain stem reticular structure accumulation of excessive, so that the transmission of nerve impulses obstacles, resulting in neurological disorders. Third, plasma amino acid imbalance theory. Severe liver disease, there will be amino acid imbalance, resulting in brain pseudo-neurotransmitters, and inhibitory neurotransmitters increased, while normal neurotransmitters decreased, resulting in central nervous system dysfunction.