Can methotrexate cure rheumatoid arthritis?

Methotrexate

is one of the most important drugs in the treatment of rheumatoid arthritis. Methotrexate has strong anti-inflammatory and immunomodulatory effects. It inhibits the proliferation and activation of immune cells by inhibiting intracellular dihydrofolate reductase and interfering with purine and pyrimidine synthesis. It has significant effects on the control of rheumatoid arthritis, effectively relieving joint pain, swelling and stiffness, and improving patients 'quality of life. Long-term regular use can delay the progression of joint damage and help protect joint function.

Tolerance and response to methotrexate may vary from patient to patient. Doctors need to adjust the dosage and regimen according to factors such as patient age, severity of disease, and comorbid diseases. At the same time, adverse reactions such as gastrointestinal discomfort, abnormal liver function, and bone marrow suppression should be closely monitored so that treatment can be adjusted in time.