Why is acute pancreatitis coagulative necrosis?

Acute pancreatitis coagulation necrosis may be related to inflammatory reaction, intestinal flora infection, fibrinolytic dysfunction and other factors, the specific analysis is as follows:

1. Inflammatory reaction

Acute pancreatitis is caused by inflammation of pancreatic tissue, inflammatory reaction can lead to vasodilation, promote vascular permeability increase and inflammatory cells and immune cells aggregation, will make the tissue ischemia and hypoxia, cause coagulation necrosis.

2. Intestinal flora infection

Pancreatitis may be related to microbial infection of intestinal flora, toxins produced by bacteria may further damage pancreatic tissue, so that local coagulation necrosis occurs.

3. Fibrinolytic dysfunction

Acute pancreatitis can lead to coagulation and fibrinolytic system disorder, so that coagulation factors and plasminogen in blood are activated, coagulation necrosis will occur.