Early gastric cancer screening

The three items of early gastric cancer screening are serum pepsinogen detection, serum gastrin-17 detection and Helicobacter pylori antibody detection. 1. Serum pepsinogen detection Pepsinogen is the precursor of pepsin, divided into pepsinogen I and pepsinogen II. Through the detection of its level changes, it can reflect the state and function of gastric mucosa. When gastric mucosa lesions occur, especially in early gastric cancer, serum pepsinogen I levels may decrease, and the ratio of pepsinogen I to pepsinogen II may also change, which is helpful to detect abnormal gastric mucosa. 2. Detection of serum gastrin-17 Gastrin-17 is mainly secreted by G cells in gastric antrum, and its level can be affected by pH value in stomach. At the same time, it can also reflect the functional state of gastric mucosa, and combined with other indicators can improve the accuracy of screening. 3. Helicobacter pylori antibody detection Helicobacter pylori infection is closely related to the occurrence of gastric cancer. Detection of Helicobacter pylori antibody can know whether there is a past infection or a current infection. Although Helicobacter pylori antibody positive alone cannot directly diagnose gastric cancer, it is an important risk factor for assessing gastric cancer risk, especially when combined with other screening indicators. Combined application of these three tests can improve the accuracy and reliability of early gastric cancer screening. For high-risk groups such as family history of gastric cancer, long-term bad eating habits and Helicobacter pylori infection, more attention should be paid to early gastric cancer screening and relevant examinations should be carried out regularly.