What exactly is triple therapy?

Triple therapy is a combination of three drugs, which is a common clinical treatment of Helicobacter pylori infection in the past. Triple therapy is generally a combination of proton pump inhibitors or bismuth and two antibiotics, such as omeprazole + amoxicillin + clarithromycin, lansoprazole + amoxicillin + clarithromycin, omeprazole + clarithromycin + metronidazole, lansoprazole + clarithromycin + metronidazole, etc. Triple therapy is rarely used now, and the commonly used quadruple therapy in clinical practice is bismuth + proton pump inhibitor + two antibiotics.