How is moyamoya disease caused?

At present, the exact etiology of moyamoya disease is not completely clear, but it may be related to genetic factors, vascular inflammatory reaction, hemodynamic changes and other factors. The presence of multiple cases in some families suggests that genetic factors may play an important role. 2. Vascular inflammation Autoimmune diseases or chronic inflammation may trigger inflammatory damage to the blood vessel wall, which in the long run promotes stenosis, occlusion, and abnormal proliferation of blood vessels, leading to moyamoya disease. For example, certain infections may trigger the body's immune response, affecting cerebral blood vessels. 3. Hemodynamic changes Due to some reasons, the blood supply to specific areas of the brain is insufficient. In order to maintain normal blood perfusion, it will cause compensatory changes in blood vessels. This long-term hemodynamic abnormality may gradually lead to the formation of moyamoya disease. For example, when the pathological changes of the cervical artery affect the blood supply to the brain, it may promote changes in cerebral blood vessels. It should be pointed out that the occurrence of moyamoya disease is often the result of a combination of factors, and a single factor may not be sufficient to directly cause the occurrence of the disease. Further research on moyamoya disease continues in the hope of better understanding its pathogenesis, thus providing a stronger basis for diagnosis and treatment.