Helicobacter pylori is the most serious disease.

In general, there is no direct correlation between the severity of H. pylori infection and the number of plus signs in the test.

Clinically, the severity of H. pylori infection is usually indicated by "-" and "+". If "+" in the test indicates the presence of H. pylori infection, but the severity of H. pylori infection is not determined by the number of plus signs. If H. pylori infection is detected, but there are no complications, the situation is generally not serious, and the patient can be treated with anti-H. pylori. However, if gastritis, peptic ulcer and other diseases are found in the examination, if not treated in time, serious consequences may result, even gastric cancer.