What causes portal hypertension?

Portal hypertension due to cirrhosis may be caused by portal vein blood flow obstruction, portal vein thrombosis, increased vascular resistance and other factors.

1, portal vein blood flow obstruction

cirrhosis will lead to hepatocellular necrosis, a large number of hepatocellular necrosis may cause diffuse proliferation of liver fiber tissue, so that the liver pressure increases, blocking the portal vein blood circulation, resulting in portal vein hypertension.

2, portal vein thrombosis

due to structural damage to the liver lobules, portal vein reflux obstruction, resulting in portal vein blood flow slowed down, gradually forming thrombosis, so that portal vein pressure increases.

3, vascular resistance increased

due to liver function impairment patients, resulting in 5-HT is inactivated by the liver reduced, 5-HT action on the portal vein receptor, will increase vascular resistance, resulting in portal hypertension.