Clinical significance of high creatinine index

The main sources of blood creatinine are endogenous and exogenous. Endogenous creatinine comes from the metabolism of the body's own muscles, while exogenous creatinine is the product of meat metabolism in the body. Generally speaking, the body's own muscle metabolism is constant. If the dietary habits change little, then the production of blood creatinine is relatively stable. The kidney is the main organ of creatinine excretion, creatinine is excreted by glomerular filtration, renal tubules basically do not reabsorb and no longer secrete, so glomerular filtration rate is the main factor affecting blood creatinine. High creatinine generally indicates kidney problems, but simple high blood creatinine may also be hyperthyroidism, acromegaly, etc. Therefore, when blood creatinine rises, it is necessary to do some renal examinations.