What is the relationship between rheumatic diseases and the human immune system?

Rheumatic disease is a group of diseases that cause bone, muscle, and soft tissue involvement, and this disease in its evolution, we call it connective tissue disease. It is caused by its anatomical structure, but because of this disease, it is often caused by the occurrence of the immune system in the body is not coordinated, unstable, caused by disorder, we often call rheumatic disease autoimmune disease, so this is the relationship between rheumatic disease and the immune system.