Clinical manifestations of fibrous dysplasia of bone

Bone fibrous dysplasia, which is caused by gene mutation on chromosome, is a non-hereditary disease of bone development disorder, which is more common in children and adolescents. The main symptoms of most patients are slight pain and swelling of diseased bone. Physical examination may show deep tenderness locally. Lower limb bone may show abnormal gait. Pathological fracture is a common complication. Fracture may be obvious displacement or slight fracture. Fracture is also one of the main causes of pain. For the bone with extensive erosion, the strength decreases, and it can show fracture bending under continuous stress. The most common fracture is proximal femoral fracture and proximal tibial fracture, which occurs in femur. Due to pathological fracture and stress fracture, deformity occurs, forming coxa varus and severe shepherd crutch deformity.