What are the causes of increased total bile acid?

The increase of total bile acid can be divided into physiological and pathological. Physiological increase often shows a transient mild increase after eating, and generally returns to normal within a certain time after eating. Pathological increase has many reasons: various liver damage, liver failure and liver diseases such as liver cancer, liver cirrhosis, acute icteric hepatitis, chronic severe liver and drug-induced liver damage, etc., as well as biliary obstruction, pyloric insufficiency and portal shunt. Pathological increase of total bile acid will be shown.