Treatment of organizing pneumonia

The treatment of organizing pneumonia depends mainly on glucocorticoids, some patients may use immunosuppressants, in addition, antifibrotic drugs can also be used to treat organizing pneumonia. Organizing pneumonia is an unknown etiology, mainly characterized by fibrin exudation and organization in the alveoli. Glucocorticoid is the main drug in the treatment of organizing pneumonia. Glucocorticoid has a good effect on idiopathic organizing pneumonia, but it has a poor effect on secondary organizing pneumonia. In addition, immunosuppressants and antifibrotic drugs can also be used to treat organizing pneumonia. 1. Idiopathic organizing pneumonia Idiopathic organizing pneumonia is an inflammatory disease of the lungs of unknown cause, which occurs in middle-aged and elderly people, more males than females. The clinical manifestations of idiopathic organizing pneumonia are mainly cough, expectoration, dyspnea, etc. Some patients may be accompanied by fever, night sweats and other symptoms. The diagnosis of idiopathic organizing pneumonia depends on clinical manifestations, chest imaging and pathological examination. Chest imaging often shows multiple nodular and patchy shadows in both lungs, which may be accompanied by pulmonary consolidation.

Pathological examination showed a large number of fibrous tissue hyperplasia and organization in the alveoli, widening of alveolar septa and destruction of alveolar structure. Treatment of idiopathic organizing pneumonia mainly depends on glucocorticoids, some patients can be combined with immunosuppressants. The dosage and duration of glucocorticoids should be determined according to the severity of the patient's disease and response to treatment. In general, glucocorticoids are given at a higher initial dose and over a longer period of time, followed by gradual reductions. During glucocorticoid therapy, attention should be paid to monitoring adverse drug reactions, such as infection and osteoporosis. 2. Secondary organizing pneumonia Secondary organizing pneumonia refers to organizing pneumonia caused by other diseases. Common causes include infection, drugs, autoimmune diseases, tumors, etc. The clinical manifestations and chest imaging findings of secondary organizing pneumonia are similar to those of idiopathic organizing pneumonia, but the treatment methods are different. For secondary organizing pneumonia caused by infection, active anti-infection treatment should be given. For drug-induced secondary organizing pneumonia, suspect drugs should be discontinued. For secondary organizing pneumonia caused by autoimmune diseases, active treatment should be given to the primary disease. For secondary organizing pneumonia caused by tumors, appropriate treatment should be given according to the type and stage of the tumor. 3. Other treatment methods In addition to glucocorticoids and immunosuppressants, antifibrotic drugs, antioxidants, cytokine modulators, etc. can also be used to treat organizing pneumonia. In addition, lung rehabilitation therapy, oxygen therapy, etc. can also improve the quality of life of patients. In short, the treatment of organizing pneumonia mainly includes glucocorticoids, immunosuppressants, anti-fibrotic drugs, etc., some patients can use a combination of drugs. Treatment should be selected according to the specific conditions of patients, and attention should be paid to the occurrence of adverse drug reactions and complications.